Nasal Type Extranodal NK/T Cell Lymphoma With Skin Lesions as Initial Symptom:A Case Report and Review of Literatures

Objective:A case of cutaneous extranodal NK/T cell lymphoma was reported and analyzed for clinical and histopathologic features,treatment and prognosis,in order to increase understanding of the disease for dermatologists. Methods:Analysis of the clinical manifestations and histopathologic features of the patient was made.Immunohistochemical staining and in situ hybridization for EBER were performed. Results:Histopathological examination of lesions on posterior neck revealed several large focal infiltrates of lymphoid cells around vessels and appendages in the superficial and middle layer of dermis.The lymphoid cells showed clear cytoplasm and large nuclei with cellular atypia.Immunostaining demonstrated that the atypical lymphoid cells expressed CD2,CD3,CD5,CD7,CD8,Granzyme B and Ki-67 but not CD56.EBER in situ hybridization showed positive result.All results above coincided with the diagnosis of cutaneous extranodal NK/T cell lymphoma. Conclusion:Nasal type cutaneous extranodal NK/T cell lymphoma has particular pathological and immunohistochemical features,but it is easily misdiagnosed.Proper diagnosis is key since NK/T cell lymphoma is a high-grade malignancy with poor prognosis.