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2007•Journal of Practical Medical TechniquesRequires access

Clinical Value of Combined Detection of AFP, CEA and CA199 in the Diagnosis of Primary Liver Cancer

Ni Wang

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Abstract

Objective To study the clinical value of combined detection of the serum levels of AFP, CEA and CA199 in the early diagnosis of primary liver cancer. Methods The serum levels of AFP, CEA and CA199 in 51 patients with primary hepatic carcinoma, 75 patients with benign liver disease (hepatic cirrhosis, chronic hepatitis)were measured by Electrochemiluminescence. Results Sensitivities of AFP, CEA and CA199 in primary liver cancer group were 74.5%,49.0% and 45.1%,respectively. They were significantly higher than those in benign liver disease (P0.05). Sensitivity of combined detection of three kinds of tumor markers was 92.2%. It was significantly higher than that of single one. Conclusion The detection of AFP, CEA and CA199 are helpful in diagnosis and in differential diagnosis of primary hepatic carcinoma. Combined detection of the three tumor markers increases the detective positive rate.

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What this paper is about

Objective To study the clinical value of combined detection of the serum levels of AFP, CEA and CA199 in the early diagnosis of primary liver cancer. Methods The serum levels of AFP, CEA and CA199 in 51 patients with primary hepatic carcinoma, 75 patients with benign liver disease (hepatic cirrhosis, chronic hepatitis)were measured by Electrochemiluminescence. Results Sensitivities of AFP, CEA and CA199 in primary liver cancer group were 74.5%,49.0% and 45.1%,respectively. They were significantly higher than those in benign liver disease (P0.05). Sensitivity of combined detection of three kinds of tumor markers was 92.2%. It was significantly higher than that of single one. Conclusion The detection of AFP, CEA and CA199 are helpful in diagnosis and in differential diagnosis of primary hepatic carcinoma. Combined detection of the three tumor markers increases the detective positive rate.

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Available abstract

Objective To study the clinical value of combined detection of the serum levels of AFP, CEA and CA199 in the early diagnosis of primary liver cancer. Methods The serum levels of AFP, CEA and CA199 in 51 patients with primary hepatic carcinoma, 75 patients with benign liver disease (hepatic cirrhosis, chronic hepatitis)were measured by Electrochemiluminescence. Results Sensitivities of AFP, CEA and CA199 in primary liver cancer group were 74.5%,49.0% and 45.1%,respectively. They were significantly higher than those in benign liver disease (P0.05). Sensitivity of combined detection of three kinds of tumor markers was 92.2%. It was significantly higher than that of single one. Conclusion The detection of AFP, CEA and CA199 are helpful in diagnosis and in differential diagnosis of primary hepatic carcinoma. Combined detection of the three tumor markers increases the detective positive rate.

Key concepts: Medicine, Cirrhosis, Internal medicine, Differential diagnosis, Gastroenterology, Liver cancer, Hepatocellular carcinoma, Alpha-fetoprotein

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Clinical Value of Combined Detection of AFP, CEA and CA199 in the Diagnosis of Primary Liver Cancer — Research Paper | ScholarLens