Applied research on AFP,CEA and CA199 combined detection in the diagnosis of primary liver cancer

Objective To investigate the clinical value on AFP,CEA and CA199 combined detection in the diagnosis of primary liver cancer.Methods 153 patients with primary liver cancer were selected in our hospital from January 2009 to June 2012 as the observation group.After clinical pathological diagnosis,the patients were divided into two groups: 94 patients were benign as the observation groupⅠ.59 patients were malignant as the observation groupⅡ.70 health physical examination personnel were selected in our hospital at the same period as the control group.All personnel were detected AFP,CEA,CA199.Clinical value was compared between individual detection and joint detection.Results AFP,CEA,CA199 in the observation groupⅡ were significantly higher than those in the control group and the observation groupⅠ.AFP,CEA,CA199 in the observation group Ⅰwere significantly higher than those in the control group.AFP,CEA,CA199 of patients with tumor stage Ⅱ,Ⅲ were significantly higher than those of patients with tumor stage Ⅰ.AFP,CEA,CA199 of patients with metastatic cancer cells were significantly higher than those of patients without metastatic tumor.Specificity from high to low was AFP,CEA,CA199,combined detection.Sensitivity from high to low was combined detection,AFP,CA199,CEA.Accuracy from high to low was combined detection, AFP,CEA,CA199.The difference were all statistically significant(all P 0.05).Conclusion AFP,CEA and CA199 combined detection can significantly improve the diagnosis accuracy of primary liver cancer,which has high sensitivity.That is worthy of clinical use.