The study of TCT and DNA quantitive cytology in the diagnosis of cervical lesions

Objective To evaluate the diagnostic value of cervical cytology combined with DNA quantitive cytology for cervical lesions.Methods From February 2006 to December 2007,2,800 patients were examined with liquid-based ThinPrep cytologic test(TCT) and DNA quantitative cytology.The patients with abnormal TCT or DNA quantitative cytology results were re-examined after three months.The patients with abnormal TCT results and atypical squamous cells of uncertain significance(ASCUS) were further examined by colposcopy and multi-site biopsy examinations.Results Abnormal TCT results were found in 302 patients(10.79%),ASCUS,low-grade squamous intraepithelial lesions(LSIL),high-grade squamous intraepithelial lesion(HSIL) and squamous cell carcinoma(SCC) were found in 194(6.93%),34(1.21%),18(0.64%) and 3 patients(0.10%),respectively.Pathological examination confirmed inflammation in 198 cases,accounting for 65.56%(198/302) of abnormal TCT.The difference in TCT and human papillomavirus(HPV) infection diagnosis was significant(P0.01).Conclusion The combined examinations of cervical cytology,DNA quantitative cytology and pathology can provide early detection of cervical cancer and precancerous lesions.