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STUDY OF ANTI-HEPATIC FIBROSIS EFFECT OF IFN-α-1b ON PATIENTS WITH CHRONIC HEPATITIS B

Xin C

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Abstract

Objective To assess the anti-hepatic fibrosis effect of IFN-α-1b on patients with chronic hepatitis B. Methods The patients were rondamly divided into IFN-treated group and control group.The serum levels of HA,LN,PcⅢ and CL-Ⅳ were observed before and after treatment. Results After treatment with IFN-α-1b,the levels of HA,LN,PcⅢ and CL-Ⅳ were significantly decreased than those before treatment and those of controls(t=1.77-3.63,P0.05).The duplication rate of HBV in IFN group was significantly decreased after IFN-α-1b treatment. Conclusion IFN-α-1b treatment brings better anti-hepatic fibrosis effect on patients with chronic hepatitis B.

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What this paper is about

Objective To assess the anti-hepatic fibrosis effect of IFN-α-1b on patients with chronic hepatitis B. Methods The patients were rondamly divided into IFN-treated group and control group.The serum levels of HA,LN,PcⅢ and CL-Ⅳ were observed before and after treatment. Results After treatment with IFN-α-1b,the levels of HA,LN,PcⅢ and CL-Ⅳ were significantly decreased than those before treatment and those of controls(t=1.77-3.63,P0.05).The duplication rate of HBV in IFN group was significantly decreased after IFN-α-1b treatment. Conclusion IFN-α-1b treatment brings better anti-hepatic fibrosis effect on patients with chronic hepatitis B.

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Available abstract

Objective To assess the anti-hepatic fibrosis effect of IFN-α-1b on patients with chronic hepatitis B. Methods The patients were rondamly divided into IFN-treated group and control group.The serum levels of HA,LN,PcⅢ and CL-Ⅳ were observed before and after treatment. Results After treatment with IFN-α-1b,the levels of HA,LN,PcⅢ and CL-Ⅳ were significantly decreased than those before treatment and those of controls(t=1.77-3.63,P0.05).The duplication rate of HBV in IFN group was significantly decreased after IFN-α-1b treatment. Conclusion IFN-α-1b treatment brings better anti-hepatic fibrosis effect on patients with chronic hepatitis B.

Key concepts: Medicine, Chronic hepatitis, Gastroenterology, Internal medicine, Hepatic fibrosis, Fibrosis, Interferon, Liver fibrosis

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