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2006•Chinese Journal of Neurosurgical Disease ResearchRequires access

Expression of interleukin-6 mRNA in the hippocampus of mice exposed to infrasound

Jingzao Chen

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Abstract

Objective To study the change of interleukin-6(IL-6) mRNA in the hippocampus of mice exposed to infrasound of different sound pressure.Methods The BALB/C mice were exposed to infrasound of 16 Hz with(intensity) of 90 dB and 130 dB for 1,7,14,21 and 28 d,2 h per day.Then in situ hybridization technique was(employed) to detect the change of IL-6 mRNA in the brains of the mice.Results The expression of IL-6 mRNA(increased) in the hippocampus regions after exposed to infrasound of 90 dB and 130 dB.The effect of 130 dB(infrasound) was large than that of 90 dB.Conclusion The extent of IL-6 mRNA change is closely related to the action time under infrasound of the same sound pressure level.Infrasound brings about brain injury through the change of IL-6 mRNA in the hippocampus,which is one of the important factors,by which the infrasound cause brain injury.

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Objective To study the change of interleukin-6(IL-6) mRNA in the hippocampus of mice exposed to infrasound of different sound pressure.Methods The BALB/C mice were exposed to infrasound of 16 Hz with(intensity) of 90 dB and 130 dB for 1,7,14,21 and 28 d,2 h per day.Then in situ hybridization technique was(employed) to detect the change of IL-6 mRNA in the brains of the mice.Results The expression of IL-6 mRNA(increased) in the hippocampus regions after exposed to infrasound of 90 dB and 130 dB.The effect of 130 dB(infrasound) was large than that of 90 dB.Conclusion The extent of IL-6 mRNA change is closely related to the action time under infrasound of the same sound pressure level.Infrasound brings about brain injury through the change of IL-6 mRNA in the hippocampus,which is one of the important factors,by which the infrasound cause brain injury.

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Available abstract

Objective To study the change of interleukin-6(IL-6) mRNA in the hippocampus of mice exposed to infrasound of different sound pressure.Methods The BALB/C mice were exposed to infrasound of 16 Hz with(intensity) of 90 dB and 130 dB for 1,7,14,21 and 28 d,2 h per day.Then in situ hybridization technique was(employed) to detect the change of IL-6 mRNA in the brains of the mice.Results The expression of IL-6 mRNA(increased) in the hippocampus regions after exposed to infrasound of 90 dB and 130 dB.The effect of 130 dB(infrasound) was large than that of 90 dB.Conclusion The extent of IL-6 mRNA change is closely related to the action time under infrasound of the same sound pressure level.Infrasound brings about brain injury through the change of IL-6 mRNA in the hippocampus,which is one of the important factors,by which the infrasound cause brain injury.

Key concepts: Infrasound, Hippocampus, Messenger RNA, In situ hybridization, Interleukin 1β, Internal medicine, Biology, Interleukin

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