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P53 mRNA expression in hippocampus of mice exposed to high intensity infrasound

Ling Li

Open publisher page 1 citations

Abstract

Objective:To explore the change of P53mRNA in the hippocampus of mice exposed to infrasound of high sound pressure.Method:BALB/C mice were exposed to infrasound of 16Hz 130dB for 2h everyday and lasted for 1,7,14,21 and 28d respectively. In situ hybridization was used to study the expression of P53mRNA in hippocampus. Result: P53mRNA in hippocampus increased after exposed to 130 dB infrasound. Under the same sound pressure level,P53mRNA in hippocampus increased along with the increase of exposure time.Conclusion: Hippocampus is sensitive to infrasound. By effects on P53 mRNA,infrasound may damage the brain. In the meantime,P53 mRNA is an important factor for the brain injury caused by infrasound. The effects related to the sound pressure level and exposure time of infrasound.

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What this paper is about

Objective:To explore the change of P53mRNA in the hippocampus of mice exposed to infrasound of high sound pressure.Method:BALB/C mice were exposed to infrasound of 16Hz 130dB for 2h everyday and lasted for 1,7,14,21 and 28d respectively. In situ hybridization was used to study the expression of P53mRNA in hippocampus. Result: P53mRNA in hippocampus increased after exposed to 130 dB infrasound. Under the same sound pressure level,P53mRNA in hippocampus increased along with the increase of exposure time.Conclusion: Hippocampus is sensitive to infrasound. By effects on P53 mRNA,infrasound may damage the brain. In the meantime,P53 mRNA is an important factor for the brain injury caused by infrasound. The effects related to the sound pressure level and exposure time of infrasound.

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Available abstract

Objective:To explore the change of P53mRNA in the hippocampus of mice exposed to infrasound of high sound pressure.Method:BALB/C mice were exposed to infrasound of 16Hz 130dB for 2h everyday and lasted for 1,7,14,21 and 28d respectively. In situ hybridization was used to study the expression of P53mRNA in hippocampus. Result: P53mRNA in hippocampus increased after exposed to 130 dB infrasound. Under the same sound pressure level,P53mRNA in hippocampus increased along with the increase of exposure time.Conclusion: Hippocampus is sensitive to infrasound. By effects on P53 mRNA,infrasound may damage the brain. In the meantime,P53 mRNA is an important factor for the brain injury caused by infrasound. The effects related to the sound pressure level and exposure time of infrasound.

Key concepts: Infrasound, Hippocampus, Biology, Endocrinology, Physics, Acoustics

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