2010•Journal of Hebei North UniversityRequires access

Clinical Significance Exprssion of P-gplycoprotein and Lung Resistance Protein in Breast Cancer

Xin Li

Abstract

Objective:To study the clinical significance of P-gplycoprotein(P-gp)and lung resistance protein(LRP)expression in breast cancer.Methods:The LRP and P-gp were detected by immunohistochemistry in 86 cases breast cancer.Results:The positive rates of P-gp and LRP were 29.07%(25/86)and 69.77%(60/86)respectively in breast cancer.The positive rates of the infiltrating cancer group and lymph node metastasis were higher(P0.05).Conclusion:The positive rates of LRP were signification higher than P-gp expression(P0.05).The expressions of P-gp and LRP is lower concerned to breast cancer.The detection on expressions of P-gp and LRP in breast cancer play a role for planning chemotherapy regimen.

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Key concepts: Breast cancer, Medicine, Lung cancer, Immunohistochemistry, Oncology, Clinical significance, Internal medicine, Chemotherapy