Expressions of P-glycoprotein and lung resistance protein in invasive breast carcinoma tissues and clinical significance

Objective To investigate the expressions of P-glycoprotein(P-gp) and lung resistance protein(LRP)in breast carcinoma tissues and their clinical significance.Methods Single-cell suspension with intact cellular membrane taken from breast cancer resection specimens were prepared using rubbing-net technique and flow cytometry(FCM)was used to quantitatively examine the expressions of P-gp and LRP in carcinoma tissues and corresponding peri-carcinoma tissues in 40breast cancer cases.Results The expressions of P-gp and LRP in breast cancer tissues were statistically different from those of the corresponding peri-carcer tissues(P0.050).No statistically significant difference existed in the P-gp and LRP expressions of the tumor cells in age,tumor size,pathological types,clinical stages and cell differentiation degree,and between negative and positive expressions of the estrogen and progestin receptors of the patients(P0.05).There was no statistical difference in P-gp expression between the lymph node metastasis negative and positive patients(t=0.102,P=0.919).The expression of LRP was higher in the lymph node metastasis patients(41.2±18.5)%than that in the non-metastasis patients(30.1± 15.4)%(t=2.074,P=0.045).There was a positive correlation between the expression of P-gp and the expression of LRP(r=0.698,P0.001).Conclusions The results of this study provides references in looking for effective chemotherapy drugs for invasive breast cancer.