ANALYSIS ON DISTRIBUTION AND ANTIBIOTIC RESISTANCE OF STENOTROPHOMONAS MALTOPHILIA IN NOSOCOMIAL INFECTION FROM 2005 TO 2009

[Objective]To investigate the infection characteristics and drug-resistance tendency of strains isolated from nosocomial infection patients with Stenotrophomonas maltophilia from 2005 to 2009.[Methods]A total of 111 patients with Stenotrophomonas maltophilia infection were studied retrospectively from 2005 to 2009 to research the strains distribution and drug resistance profiles.[Results]Nosocomial infection of Stenotrophomonas maltophilia was increasing year after year.111 strains of Stenotrophomonas maltophilia were mainly isolated from sputum(58.56%)specimen.The resistance rate of the Stenotrophomonas maltophilia to ciprofloxacin was increasing year after year,while that to compound sulfamethoxazole tended to decrease.[Results]The susceptibility test showed that the resistance rate of the Stenotrophomonas maltophilia to all the 10 β-lactams were high except Cefoperazone/Sulbactam(lower than 35%)and Ticarcillin/Clavulanic acid(lower than 51%).And the resistance rate to Gentamicin and Amikacin were both higher than 85%.The resistance rate of Minocycline was the lowest(lower than 8%)among all the antibiotics,followed by Levofloxacin and Sulfamethoxazole/Trimethoprim,both lower than 26%.[Conclusion]It is indicated that the infection rate of the Stenotrophomonas maltophilia is increasing year after year.And the Stenotrophomonas maltophilia is highly resistant to the common antibiotics,so there are few antibiotics for the clinicians to choose.The pathogenic inspect is recommended as early as possible to avoid the outbreak of the nosocomial infection.