Effect of Lornoxicam on the Serum Levels of IL-2,IL-6 and IL-10 in Perioperative Period of Patients Undergoing Cholecystectomy

Objective To explore the effects of Lornoxlcam on the serum of IL-2,IL-6 and IL-I0 in perioperative period of patients undergoing cholecystectomy and to study the mechanism of Lornoxicam on immunologic function. Methods forty patients scheduled for cholecystectomy operations were randomly allocated to either A or B group,each with 20 cases. The luminal and atropine was routinely used before operations. The patients in group A were intravenous dripped with 8mg of Lornoxicam before anesthesia,and then given Sufentanil to patient controlled intravenous anesthesia(PCIA). The patients in group B were intravenous dripped with 8mg of Lornoxicam at the end of the abdominal closure,and then given Sufentanil to the PCIA. The serum of interleukin-2(IL-2),Interleukin-6(IL-6) and Interleukin-10(IL-10) in all patients were measured at prior to anesthesia medication(T1),abdominal closure end immediately(T2),6 hours after surgery( T3) and 24hours after surgery(T4). Results There was no significant difference between the two groups in the levels of IL-2,IL-6 and IL-10 at T1 time point s(P 0. 05). The levels of IL-2 and IL-6 in group B were significantly higher than that of in group A at the T2,T3 and T4 time points(P 0. 05). The levels of IL-10 in group B were significantly lower than that in group A at the T2,T3 and T4 time points( P 0. 05). Conclusion Compare with the post-operation,the preoperative use of Lornoxicam could mitigate factors such as anesthesia,surgery on the inhibition of cellular immune function,and can effectively inhibit stress response in favor of postoperative recovery.