The Influence of Timing of Administration on Postoperative Analgesia,IL-6 and IL-10 of Lornoxicam in Unilateral Thyroidectomy with Neck Dissection

Objective:To study the influence of timing of administration on postoperative analgesia and cytokines of lornoxicam.Methods:Sixty patients scheduled for unilateral thyroidectomy with neck dissection under general anesthesia were enrolled,all patients were divided into 3 groups(20 patients each group),to the following IV dosing schedule:(1) saline 5ml at induction(T1),at wound closure(T2),and 4 h after induction(T3)(control group);(2) lornoxicam 0.1mg·kg-1 at T1 and T3(pre-group);(3) lornoxicam 0.1mg·kg-1 at T2 and T3(post-group).Visual analog scores(rest and exercises) were assessed at 1 h,4 h,and 24 h postoperation.The plasma concentrations of IL-6 and IL-10 were assessed at 30 min preoperation and at the same time above.Results: Differences in VAS(r) and VAS(e) were found between the control group and the pre-group(P0.05).at 4 h and 24 h postoperation IL-6 and IL-10 concentrations increased,reaching peak levels at 4 h after surgery respectively in three groups,and reduced after 4 h.IL-10 concentrations came back to the baseline at 24 h.At 1 h,4 h and 24 h,the IL-6 concentrations in control group were significantly highest among three groups(P0.05).At 4 h,the IL-6 concentration was significantly higher in post-group than that in pre-group(P=0.039).In contrast,IL-10 concentrations at 1 h and 4 h were lower in control group than those in pre-group(P=0.02 and 0.04,respectively).At 4h,IL-10 concentration was lower in control group than that in post-group(P=0.02).Conclusion:Preoperative lornoxicam may have a pain-releiving role in unilateral thyroidectomy with neck dissection.Both preoperative lornoxicam and postoperative lornoxicam may have anti-inflammatory roles.