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2007•Journal of Pharmaceutical and Biomedical SciencesRequires access

Mapping and Tissue Expression of Porcine Tool-like Receptor 4(TLR4)

Qin Zhang

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Abstract

Analysis of radiation hybrid panel indicated that porcine Tool-like Receptor 4 (TLR4 ) gene was closely linked to the marker SW1957 (15 cR, LOD score 15.16) which was located on porcine chromosome 1 q2.9→q2.13. Using RT-PCR analysis, porcine TLR4 transcripts were detected in testicle, grey matter, skeletal muscle, white matter, kidney, heart, small intestine, thymus, lymph node, spleen, lung and liver, and the hightest level expression in lung. The TLR4 mRNA expression in lung may affect porcine pulmonary disease.

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What this paper is about

Analysis of radiation hybrid panel indicated that porcine Tool-like Receptor 4 (TLR4 ) gene was closely linked to the marker SW1957 (15 cR, LOD score 15.16) which was located on porcine chromosome 1 q2.9→q2.13. Using RT-PCR analysis, porcine TLR4 transcripts were detected in testicle, grey matter, skeletal muscle, white matter, kidney, heart, small intestine, thymus, lymph node, spleen, lung and liver, and the hightest level expression in lung. The TLR4 mRNA expression in lung may affect porcine pulmonary disease.

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Available abstract

Analysis of radiation hybrid panel indicated that porcine Tool-like Receptor 4 (TLR4 ) gene was closely linked to the marker SW1957 (15 cR, LOD score 15.16) which was located on porcine chromosome 1 q2.9→q2.13. Using RT-PCR analysis, porcine TLR4 transcripts were detected in testicle, grey matter, skeletal muscle, white matter, kidney, heart, small intestine, thymus, lymph node, spleen, lung and liver, and the hightest level expression in lung. The TLR4 mRNA expression in lung may affect porcine pulmonary disease.

Key concepts: Biology, TLR4, Spleen, Lung, Receptor, Lymph node, Pathology, Messenger RNA

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