Morphine-sparing effect of flurbiprofen axetil for postoperative patient controlled analgesia

Objective To investigate the morphine-sparing effect of intravenous flurbiprofen axetil for postoperative patient-controlled analgesia. Methods 30 patients(ASA I—II) undergoing malignancy total correction procedure in gynecology were randomly divided into three groups:morphine alone 0.3 mg/ml-1 at the end of the procedure(Group M) ,adding flurbiprofen axetil 50mg at the end of the procedure(Group F1) and at the 8 hours after operation(Group F2) respectively.VAS were used to evaluate the analgesic response. Results Patients in the three analgesic groups did not show significant differences in the VAS values(P0.05) .Total morphine consumption,PCA pressing times and effective times in group M were significantly more than those in group F1 and group F2(PO.05) .The incidence of nausea and vomiting was highest in group M and the incidence of pruritus was the same in all the group. Conclusion The dual add-on postoperative intravenous administration of flurbiprofen axetil to the morphine regimen can spare morphine consumption and dcrease side effects.