Effect of Flurbiprofen Axetil on Improvement of Morphine for Postoperative Analgesia

Objective To investigate the effect of flurbiprofen axetil on morphine-sparing in postoperative patient-controlled analgesia.Methods Thirty ASA Ⅰ~Ⅱ patients with gynecologic malignant tumor were randomly divided into three groups,flurbiprofen axetil were administrated at different time point for different times,respectively,and the postoperative patient-controlled analgesia was given simultaneously.The analgesic effect was evaluated with visual analogue scale(VAS),the dosage of analgesic drug and the side effects were recorded.Results At 24 h and 48 h postoperation,the VAS value had no significant difference in the three groups(P0.05);the total dosage of morphine,the press time of PCA and the effective times in group F1 and group F2 were significantly different from those in group M(P0.05 or P0.01);the incidence of side effects including nausea,vomiting and pruritus in group M was higher than that in group F1 and group F2,while the incidence of dizziness had no significant difference in the three groups.Conclusion Flurbiprofen axetil could effectively improve the postoperative patient-controlled analgesia,decrease the dosage of morphine as well as its side effects.