The Influence of Flurbiprofen Axetil on Doses and Effect of Morphine for Patients with Moderate to Severe Postoperative Pain

Objective To compare analgesic efficacy on postoperative analgesia with flurbiprofen axetil combined morphine and with morphine alone.Methods Sixty patients undergoing elective abdominal or thoracic surgery were randomly divided into three groups with twenty patients each.Group M was given morphine 50 mg diluted to 100 mL via PCA after surgery.Group F1 was administrated with flurbiprofen axetil before operation,and morphine 50 mg diluted to 100 mL via PCA after surgery.Group F2 was given flurbiprofen axetil plus morphine 50 mg diluted to 100 mL via PCA after surgery.The set of PCA were the same for three groups,bolus 2 mL,lock time 5 min,maximum volume 20 mL per hour.VAS score was assessed at 2 h,8 h and 24 h postoperative,doses of morphine needed at 24 h and side effects were recorded.Results There was no significant difference in VAS score at 2,8 and 24 h among three groups(P0.05).Doses or morphine needed in F1 group and F2 group were a little lower than that in M group,but there were no significant difference among three groups(P0.05).There were no significant difference in side effects either(P0.05).No respiratory depression or gastrointestinal bleeding occurred in three groups.Conclusion Preemptive with flurbiprofen aextil 50 mg and flurbiprofen axetil 100 mg administrated via PCA both show good analgesic effect,and can reduce morphine requirement for middle to old age patients with moderate to severe postoperative pain,though without significant difference in dose.