The treatment effect of Guishen Granule on experimental type II diabetes in rats

Objective To study the effcct of Guishen granule on the levels of body weight,blood glucose,triglyceride and C peptide in exprimental type Ⅱ diabetic rats Method 50 male SD-rats were divided into 7 groups including control group,hyperlipidema group,high dose traditional Chinese drug group,middle dose group,low dose group,Jiangtangshu group and model group Blood samples of all groups were collected on 12 hours after fasting and on 2 hours after diet when all rats had been treated for 4 weeks Blood glucose,triglyceride and C peptide of all groups were detected Result Hyperglycemia,hypertriglyceridemia and low fasting C peptide existed in the diabetic rats The levels of C peptide on 2 hours after diet in the high and middle dose drug groups increased to the levels which were similar to that of the control group(P0 05),while those of the low dose group,jiangtangshu group and model group were still significant lower when compared with that of the control group(P0 05) The fasting glucose of high dose group was remarkably lower than those of the other diabetic groups (P0 05) Conclusion Guishen granule could improve the symptoms,reduce the level of blood glucose and increase the level of c peptide of the diabetic rats