Hypoglycemic effect of Xiansangyin on diabetic mice

Objective To observe the hypoglycemic effect of Xiansangyin on diabetic mice. Methods Twelve in eighty male mice were randomly selected as control group,and the rest were induced as diabetic model by alloxanate. Sixty mice of which fasting blood glucose value≥11.1 mmol/L were randomly divided into model group,metformin group as well as Xiansangyin groups(low-dose,medium-dose and high-dose). The number of mice in each group was 12,and 0.9% sodium chloride solution 20 mL/kg,metformin 0.15 g/kg as well as Xiansangyin 0.8,1.6 and 3.2 g/kg were administrated respectively. The effect of Xiansangyin was evaluated by blood glucose value and signs(body weight,feeding amount and drinking amount)before and after administration. Results Compared with pre-administration,the level of blood glucose as well as feeding and drinking amount in Xiansangyin groups(medium-dose and high-dose) decreased significantly than those in model group after administration(P0.05 or P0.01),and the grade of weight-loss in Xiansangyin high-dose group was significantly lower than that in model group(P0.05). Conclusion Xiansangyin can lower the level of blood glucose in diabetic mice effectively. It might be helpful to the improvement of signs of diabetic mice.