The role and significance of enteral nutrition to the expression of TGF-β1 in the mucosa of the small intestine of rats with obstructive jaundice

Objective To study the role and significance of enteral nutrition to the expression of TGF-β1 in the mucosa of the small intestine of rats with obstructive jaundice.Methods 40 Wistar rats were randomly divided into normal control group,sham operated group,obstructive jaundice(OJ) group,and obstructive jaundice group with Nutrition(OJ+EN).The OJ+EN group was supplied with enteral nutrition for 10 days,with the total energy supply at 630 kJ/(kg·d)and the nitrogen content at 1.0 g/(kg·d).The expression of TGF-β1 in intestinal mucosa was tested by immunohistochemical methods.Results The TGF-β1 expression in the intestinal mucosa membrane of the OJ group decreased(P0.01);the TGF-β1 expression of the OJ+EN group increased significantly compared with the OJ group(P0.01).Conclusion The expression of TGF-β1 in intestinal mucosa cell was significantly reduced when obstructive jaundice occurs.Enteral nutrition helps heal the damage of the intestinal mucosa caused by obstructive jaundice,which might be attributable to promote the secretion of TGF-β1 in of the intestinal mucosa.