Clinical efficacy of Compound Matrine Injection in treatment of hepatitis C cirrhosis and its mechanism

Objective To explore the clinical efficacy of Compound Matrine Injection in patients with hepatitis C cirrhosis and mechanism. Methods Patients with hepatitis C cirrhosis(56 cases) were randomly divided into treatment group and control group, 28 cases in each group. The control group used general protecting liver according to the condition of disease, such as vitamin C, potassium aspartate magnesium, and the treatment group added Compound Matrine Injection, id, 600 mg/d. One treatment course was for 3 months, then the efficacy, liver fibrosis, peripheral mononuclear cells secreting cytokines, and mRNA of IL-10 were evaluated after continuous treatment for two courses. Results The recovery rate of ALT in the treatment group was 34.56%, and negative rate of HCV RNA was 9.34%, and those of the control group were 21.54% and 6.53%. There was statistically significant difference between two groups(P 0.01, 0.05). The levels of HA of the two groups after treatment were lower than those before treatment. The difference between the two groups was statistically significant(P 0.01), but there was no statistically significant difference after treatment. PC-III and IV-C had no significant difference before and after treatment; The LN levels in the two groups after treatment were obviously lower than those before treatment, and the differences were statistically significant(P 0.01). The LN level of the treatment group decreased more significantly after treatment. Compared to the control group, the difference was statistically significant(P 0.01). IL-10 mRNA levels of the treatment group after treatment raised. Compared with that before treatment, the difference was statistically significant(P 0.01). IL-10 mRNA of treatment group after treatment was significantly higher than that in control group, and there was significant difference between two groups(P 0.05). IL-10 mRNA of the control group had no significant difference before and after treatment. Conclusion There is a better clinical effect of Compound Matrine Injection within the basis of conventional therapy on patients with hepatitis C cirrhosis, and its mechanism may be related to the influence of peripheral mononuclear cell IL-10 and regulating the body's inflammatory balanced realization.