Treatment with matrine and/or levamisole in chronic hepatitis B

Objective:To study the efficacy of matrine injection and/or levamisole liniment(L.L.) in treatment of chronic hepatitis B.Methods:Thirty eight patients were divided at random into 3 treatment group A,B,C and a control group.Treatment group A was given matrine injection 400 to 600 mg/d intramuscularly,group B L.L. 500 mg(5 ml) percutaneously twice a week,group C 2 drugs in combination,and the control group the general liver protection drug,vitamins.The therapeutic course was 3 months.Results:The normalization rates of serum alanine amino transfernase(ALT) and total bilirubin(TBIL) of each of the 3 treatment groups and the control group were not different significantly( P 0.05) after treatment.The negative conversion rates of there groups were not different significantly after 1 month and 2 months treatment,but after 3 months treatment,the negative conversion rate of serum HBeAg of the treatment group A,B,C were 33.3%,30.0%,38.9%,HBV DNA of the treatment group A,B,C were 46.2%,47.1%,55.0%,significantly higher than that of the control group( P 0.05).Conclusions:Matrine injection is effective in inhibiting proliferation of HBV,regulating immune reaction of the host and antagonisting liver inflammetion,so the use of matrine injection in combination with L.L. is a safe,economic,convenient and effective durg in treatment of chronic hepatitis B.