2007•Fudan xuebao. Yixue banRequires access
Expression of osteopontin and adhesion molecule CD44v6 in gallbladder cancer and their clinical significance
Qiong Li
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Abstract
Purpose To investigate expression of osteopontin (OPN) and adhesion molecule CD44v6 in gallbladder cancer and their clinical significance. Methods The expressions of OPN and CD44v6 were detected by immunohistochemical method in 38 cases of gallbladder cancer compared with 10 cases of normal gallbladder tissue and 10 cases of gallbladder adenoma. The relationship between the expression of OPN and CD44v6 was analyzed. Results The positive expressions of OPN and CD44v6 in gallbladder cancer tissues were significantly higher than that in normal gallbladder tissues and gallbladder adenoma tissues( P0.05). The positive expression of OPN in gallbladder cancer with metastasis(patients of NEVIN Ⅳ、Ⅴ stages) were much higher than that without metastasis (patients of NEVIN Ⅰ、Ⅱ、Ⅲ stages)(P0. 05). The expression of OPN was positively correlated with the expression of CD44v6 (P0.05). Conclusions The OPN-CD44v6 axis may play an important role in the metastasis of gallbladder cancer.