Distribution of Acinetobacter baumannii in Nosocomial Infection and Dynamic Changes in Antimicrobial Resistance

OBJECTIVE To find out Dynamic changes in Acinetobacter baumannii of drug resistance from year 2005 to 2007 in the Second Hospital Affiliated to Jiangxi Medial College.METHODS Susceptibility of 130 Acinetobacter baumannii to 12 clinical antibiotics commonly used were detected.RESULTS A.baumannii strains were mainly distributed at ICU wards,respiratory department and Orthopedics department,sameas the Multi-drug resistance strains.The resistance rate of A.baumannii isolates to 12 antimicrobial agents has been on a steady increase in the past 3 years,among which the resistant rate of Imipenem was 23.1%,cefoperazone/sulbactam and ampicillin/sulbactam were 30.0% and 40.0% respectively,and other antimicrobial agents were from 56.2% to 76.2%.The strains not susceptible to imipenem had resistant rates to cefoperazone/sulbactam,ampicillin/sulbactam,and ceftazidime which were 56.7%,80.0%,83.3% respectively.To other agents,the rates were over 90.0% on the average.But the strains susceptible to imipenem had resistant rates to cefoperazone/sulbactam,ampicillin/sulbactam which were 22.0%,28.0% respectively.To the other agents the rates were from 44.0% to 71.0%.CONCLUSIONS The resistance of A.baumannii has been rising steadily.Imipenem is still the most active drug in A.baumannii,followed by Cefoperazone/sulbactam.