Analysis of the drug resistance of 348 Acinetobacter baumannii isolates from the lower respiratory tract

Objective To investigate the antimicrobial resistance of Acinetobacter baumannii and changes in the prevalence of carbapenem-resistant A.baumannii.Methods A total of 348 A.baumannii specimens were collected from January 2008 to December 2010 at this hospital.Antimicrobial susceptibility was determined by the disk diffusion method.Results Of the 348 A.baumannii isolates,A.baumannii was least resistant to cefoperazone/sulbactam(14.4%),followed by imipenem(16.1%) and meropenem(18.4%);A.baumannii is increasingly resistant to routine antibiotics.The 56 A.baumannii isolates that were resistant to imipenem were most resistant to piperacillin(100%),followed by ticarcillin/clavulanic acid,aztreonam,and gentamicin.Isolates were least resistant to minocycline,followed by cefoperazone/sulbactam and ciprofloxacin.Conclusion A.baumannii has severe resistance to antibiotics.Enhancing the monitoring of drug resistance and encouraging the rational use of antimicrobials based on drug sensitivity will help protect limited resources in terms of antibiotics and provide evidence for control of nosocomial infection.