Clinicopathological analysis in serum HBV-positive glomerulonephritis

Objective:To study the relationship between clinical and pathological features in serum HBV positive glomerulonephritis.Methods:The clinical data,laboratory results and pathological findings of renal biopsies in 40 patients with serum HBV positive glomerulonephritis were analyzed.Results:The incidence of HBV related glomerulonephritis was 47.5%(19/40).Among these patients,nephritic syndrome was the main manifestation;membranous nephropathy(52.6%)and membranous proliferative glomerulonephritis(21.1%) were the principal pathological types;the positive rates of IgG, C 3 and Clq staining and the degree of tubular interstitial lesions in renal tissues,and the positive frequency of serum e antigen were superior to those in renal HBV negative group( P 0.05 0.001).Conclusion:In patients with serum HBV positive glomerulonephritis,there are obvious differences in the clinical manifestations,laboratory results and pathological types between renal HBV positive and HBV negative glomerulonephritis.Clinical manifestations and laboratory results appear to be helpful in diagnosing HBV related glomerulonephritis for lack of renal biopsy.