Comparative Analysis on the Pathogenic Effect of Hepatitis B Virus Infection on Glomerulonephritis

Objective:To observe the roles of hepatitis B virus (HBV) infection in the pathogenesis of glomerulonephritis.Methods:Forty-nine cases of glomerulonephritis with positive serum HBV markers and fifteen cases of glomerulonephritis with negative serum HBV markers were collected.HBV-markers(HBsAg、HBeAg、HBcAg)were detected by immunohistochemical techniques in these renal tissues.In addition,the clinicopathological changes of the positive group (A) and the negative group (B) were compared.Results:(1)There was no significant difference between the two groups in the sex, the age, the 24h urinary protein quota, haematuria,the liver function, the kidney function and the blood serum immunology target aspect(P0.05);(2)There was no significant difference of HBV-markers between the two groups(P0.05);(3)There was also no significant difference in pathology between the two groups (P0.05).Conclusion:This results suggests that glomerulonephritis might result from direct infection of HBV in kidney.