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Studies on the reverse of resistance using arsenic trioxide incombination with DDP in HTB-56/DDP cell lines of lung cancer

WU Guangzhou

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Abstract

Objective:To observe the effects of arsenic trioxide(As_2O_3)and cisplatin(DDP) alone or in combination on reverse of resistance in HTB-56/DDP cell lines and apoptosis-inducing effects of arsenic trioxide.Methods:The sensitivity of HTB-56/DDP cells to As_2O_3 and DDP was tested by means of MTT in vitro and the morphological changes of apoptosis were detected by electron microscopy.Results:The resistance of HTB-56/DDP cell line to DDP was 14.65 times higher than that of HTB-56,but the IC50 value of both cell lines to As_2O_3 was similar(P0.05).Cell inhibition by DDP combining with low-dose As_2O_3 was higher than that of administration alone.As_2O_3 could reinforce the sensitivity of HTB-56/DDP cells to DDP and induce apoptosis of cell lines.Conclusion:As_2O_3 might be an effective anti-tumor drug as well as an effective drug for reversal of HTB-56/DDP to DDP.

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Objective:To observe the effects of arsenic trioxide(As_2O_3)and cisplatin(DDP) alone or in combination on reverse of resistance in HTB-56/DDP cell lines and apoptosis-inducing effects of arsenic trioxide.Methods:The sensitivity of HTB-56/DDP cells to As_2O_3 and DDP was tested by means of MTT in vitro and the morphological changes of apoptosis were detected by electron microscopy.Results:The resistance of HTB-56/DDP cell line to DDP was 14.65 times higher than that of HTB-56,but the IC50 value of both cell lines to As_2O_3 was similar(P0.05).Cell inhibition by DDP combining with low-dose As_2O_3 was higher than that of administration alone.As_2O_3 could reinforce the sensitivity of HTB-56/DDP cells to DDP and induce apoptosis of cell lines.Conclusion:As_2O_3 might be an effective anti-tumor drug as well as an effective drug for reversal of HTB-56/DDP to DDP.

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Available abstract

Objective:To observe the effects of arsenic trioxide(As_2O_3)and cisplatin(DDP) alone or in combination on reverse of resistance in HTB-56/DDP cell lines and apoptosis-inducing effects of arsenic trioxide.Methods:The sensitivity of HTB-56/DDP cells to As_2O_3 and DDP was tested by means of MTT in vitro and the morphological changes of apoptosis were detected by electron microscopy.Results:The resistance of HTB-56/DDP cell line to DDP was 14.65 times higher than that of HTB-56,but the IC50 value of both cell lines to As_2O_3 was similar(P0.05).Cell inhibition by DDP combining with low-dose As_2O_3 was higher than that of administration alone.As_2O_3 could reinforce the sensitivity of HTB-56/DDP cells to DDP and induce apoptosis of cell lines.Conclusion:As_2O_3 might be an effective anti-tumor drug as well as an effective drug for reversal of HTB-56/DDP to DDP.

Key concepts: Arsenic trioxide, Cisplatin, Apoptosis, Cell culture, IC50, Cancer research, MTT assay, Chemistry

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Studies on the reverse of resistance using arsenic trioxide incombination with DDP in HTB-56/DDP cell lines of lung cancer — Research Paper | ScholarLens