Inhibitory Effect of Polypeptide P161 Combined with Cisplatin on Proliferation of Multiple Cancer Cells

Objective In vitro detection of anti-proliferative effects of P161 combined with cisplatin( DDP) on multiple cancer cells. Methods Growth inhibition rates of HepG2,HT29,IE8,Panc-1 and MA-782 treated by different concentrations of DDP,P161 and P161 combined with DDP were determined by MTT assay. Results DDP and P161 dosedependently inhibited proliferation of multiple tumor cells. A synergistic effect was found in DDP combined with P161 and there was a significant difference in the effect between DDP combined with P161 and DDP alone( P 0. 05). DDP dose could be decreased to reach the same inhibitory effect. In the same concentration gradient of DDP combined with P161,the inhibition rate of Panc-1 was low and that of MA-782 was high. Conclusion P161 can increase the sensitivity of tumor cells to DDP. The combination of P161 and DDP can reduce the effective therapeutic concentration of DDP.