Correlation Between Expression of ER,PR and C-erbB-2 in Breast Cancer and Metastasis of Axillary Lymph Nodes

Objective To explore the correlation of axillary lymph nodes metastases with the expression of ER,PR and C-erbB-2. Methods We used immunohistochemical method to detect the expression of ER,PR and C-erbB-2 in 182 cases of breast cancer. Results ①The positive rates of expression of ER,PR and C-erbB-2 in breast cancers were 42.9%,53.8%,50.5% respectively.②The positive rate of expression of C-erbB-2 in the positive group with the expression of ER,PR was lower than that in the negative group(P0.05).The positive rate of expression of C-erbB-2 in the group with the lymph node metastasis was higher than that in non-lymph node metastasis group(P0.05).③ER expression had a positive correlation with PR expression.No significant association of expression ER,PR with age,tumor diameter and histological types was noted(P0.05). Conclusion ER,PR and C-erbB-2 are concerned with the development of breast cancer.Testing ER,PR and C-erbB-2 expression is of great significance to the formulation of therapeutic scheme.