Therapeutic effect of Montelukast combined with Glucocorticoid on childhood cough variant asthma

Objective: To evaluate the therapeutic effect of the combined treatment by the oral Montelukast and inhaled Glucocorticoid on the childhood cough variant asthma.Methods: 86 cases children with cough variant asthma were selected in our hospital from January 2006 to June 2010 and divided into observation group and control group evenly.The control group only inhaled 125 μg Fluticasone propionate per time,twice a day with one in the morning and the other in the night.In the regular treatment with the inhaled Glucocorticoid,observation group was added with Montelukast orally taken 4 mg once daily before bedtime.After eight weeks with the continuous therapy,the clinical efficacy before and after treatment were compared in order to find out the influence of asthma symptom and asthma itself on the sleeping quality and daily behavior of sick children.Results: Total efficiency rate of Montelukast combined with Glucocorticoid was 95.35%,compared with the efficiency rate of control group(74.42%),there were significant differences(χ2=42.742,P0.05).The symptom score before treatment had little difference between two groups(t=0.716,P0.05),but there were significant differences after treatment(t=5.321,P0.05).Additionally it did not increase the side effect of the treatment.Conclusion: Montelukast combined with Glucocorticoid in the treatment of childhood with cough variant asthma can boost clinical efficacy greatly,and inprove symptom of sick children,deserves to be promoted and applied.