Analysis on the indications of prenatal diagnosis and results of amniocentesis in 2 250 cases

Objective:To explore the clinical significance of invasive prenatal diagnosis(amniocentesis) in women with different indications.Methods:The indications of invasive prenatal diagnosis and the detection rate of abnormal karyotypes of exfoliative cells in amniotic fluid of 2 250 pregnant women were analyzed retrospectively.Results:Among 2 250 cases,124 cases were found with abnormal karyotypes,the detection rate was 5.5%.The detection rates of abnormal karyotypes in women with different indications of invasive prenatal diagnosis were 33.3%(one of the couple with chromosomal abnormality),11.6%(abnormal foundings through fetal ultrasonography),5.1%(advanced maternal age),4.3%(prenatal serological screening abnormality),and 2.1%(Down's syndrome),respectively.Conclusion:Amniocentesis is a safe and effective invasive prenatal diagnosis method,which can prevent the birth of children with chromosomal diseases effectively.