Evaluation of Detection Rate and Safety of Amniocentesis for Chromosomal Abnormalities in 1180 Pregnant Women

Objective:The occurrence rate and the type of abnormal fetal chromosomal karyotypes by amniocentesis were investigated,the indication and safety of amniocentesis in prenatal diagnosis were evaluated.Methods:A retrospective review was done for 1180 pregnant women who had amniocentesis from January,2005 to August,2008.The indicaton,abnormal karyotypes detection rate,and procedure-related complications were reviewed.Results:Among 1180 cases,there were 43 abnormal chromosomal karyotypes(detective rate 3.6%).For the 43 abnormal karyotypes,there were 19 cases of abnormal chromosome number(44.2%),10 cases of trisomy 21(23.3%).The detection rate order of chromosomal abnormalities was:one of the couple as chromosomal abnormality carrier,history of adverse-pregnant,abnormal maternal serum screening result,abnormal ultrasonography results,advanced maternal age.The detective rate of trisomy 21 in advanced maternal age group was 0.5%,while the detective rate was 1% in young pregnant women,but there was no statistical difference(P0.05).Among the 1180 cases,there were 5 cases of spontaneous abortion,which is not rrelated with amniocentesis after investigation.Conclusions:Amniocentesis under ultrasound-guidence is a safe and reliable method for prenatal diagnosis.Indications of prenatal diagnosis should be strictly controlled to actively implement two-level intervention for improving population quality.