Serum levels of growth differentiation factor 15 and BNP in patients with acute myocardial infarction and their clinical significance

0bjective To explore the correlation between growth differentiation factor 15(GDF-15),cardiac troponin I(cTnI) and brain natriuretic peptide(BNP) in patients with acute myocardial infarction(AMI) and the short-term prognosis value of GDF-15.Methods We selected 122 subjects who had acute myocardial infarction with onset 12 h,with follow-up average 12 months and 40 normal coronary angiography(CAG) were set as control group.The serum GDF-15 and BNP were measured by enzyme-linked immunosorbent assay(ELISA);The serum cTnI were measured by immunofluorometric assay technique.The clinical main adverse cardiac events(MACE) including cardiac death,heart failure,myocardial infarction or recurrent angina pectoris were recorded during hospitalization and follow-up.Results Compared with control subjects,level of GDF-15 and BNP were higher in patients with AMI including ST-elevation myocardial infarction(STEMI) and No ST-elevation myocardial infarction(NSTEMI)(P 0.05).Positive correlations between GDF-15,cTnI and BNP were observed by Spearman correlations analysis.In the AMI patients,GDF-15 level was elevated in patients with MACE compared with patients without MACE.Multivariate logistic regression analysis revealed that the GDF-15 level was independently associated with MACE during average 12 months(odds ratio = 0.79,95% CI:0.67 ～ 0.84,P 0.05).Conclusions There is positive correlation between the level of GDF-15,cTnI and BNP.of patients with AMI.The serum level of GDF-15 is associated with short-term prognosis in patients with AMI.