B-type Natriuretic Peptide for Prognosis after Acute Myocardial Infarction

Objective To investigate the prognostic value of the plasma levels of B-type natriuretic peptide(BNP) and cardiac troponin I(cTnI) in patients with acute myocardial infarction.Methods BNP and cTnI levels at admission and the seventh day after infarction were measured by enzyme-linked immunosorbent assay(ELISA) and chemoluminescence technique.Major cardiovascular events(MACE)were recorded.Correlation between the cTnI and BNP levels and the incidence of MACE were analyzed.Results The plasma levels of BNP were significantly increased on admission in patients with AMI compared with controls(P0.01);The levels in patients who hospitalized after 10 hours of AMI onset were higher than those within 10 hours(P0.01);and in patients who died within a week after admission,the levels were much higher than those in survival patients(P0.01).Patients with elevated BNP plasma levels were at higher risk of MACE(P0.01);the incidence of MACE in BNP positive group was much higher than those in BNP negative group(P=0.044).Compared with controls,BNP concentrations in patients at the seventh day after infarction were much higher(432.79±383.82pg/ml versus 48.45±18.35pg/ml,P0.01);MACE incidence in patients with cTnI levles≥52.5 ng/mL was much higher than those in patients with cTnI levles 52.5 ng/mL at admission instantly(P0.01).In patients with higher BNP and cTnI concentration at admission instantly,the incidence of MACE increased significantly.Conclusions BNP obtained at admission and the seventh day after the onset of AMI,provide powerful information for use in predicting prognosis.he higher BNP level is,the higher hazard of the incidence MACE is.BNP associating with cTnI can increase prognostic value in patients with AMI.