Effects of Controlled-release Metoprolol Therapy on the Ventricular Remodeling and Cardiac Function in the Patients of Chronic Congestive Heart Failure

Objective To investigate cardiac function improvement with titrated controlled-release metoprolol therapy in the patients of chronic congestive heart failure(CHF).Methods In 60 patients with CHF,the ejection fraction of cardiac function was(NYHA class)classⅡ-Ⅳ.≤0.45.On a basic medical therapy including digitalis,diuretics and ACEI,they were divided randomly into metoprolol group and con- trol group for a 6-momth follow-up period.The data of ventricular function were measured by 20-echcar- diography after admission.Results In metoprolol group symptom scores and NYHA class improved,as re- flected by the increased left ventricular ejection fraction[(36.1±1.9)% vs(29.5±1.70%,P＜0.01]and the decreased left ventricular end systolic volume[(165.5±45.0)ml vs(181.0±44.0)ml,P＜0.05]; compared with those in control group.Moreover,in treatment group,the left ventricular end-diastolic volume decreased at 6-month compared with that at baseline(P＜0.05),but there was no significant differences be- tween the two groups.Conclusion Based on the medication of digitalis,diuretics and angiotensin-conver- ting enzyme inhibitors controlled-release,metoprolol therapy can improve left ventricular performance in pa- tients o congestive heart failure and also improve the biological properties of the chronically failing heart.