The effect of metoprolol on the left ventricular remodeling and cardiac function in patients with congestive heart failure

Objective To study cardiac function improvement and remodeling process with metoprolol therapy in patients with congestive heart failure.Methods 66 patients received basline therapy (digitalis,diuretic andACEI) were randomlyinto to control group and treatment group for a 6-month follow-up period.In the treatment group metoprolol was given.The data of ventricular function were measured by 20-echocardiography at baseline, 1,3 and 6 months after admission.Results In treatment group symptom scores and NYHA class improved(P0.01),as reflected by the increased left ventricular ejection fraction(LVEF)(P0.01).Conclusion Based on the medication of digitalis,diuretics and ACEI,metoprolol therapy can improve left ventricular performance,reverse LV remodeling in patients with cardiac dysfunction.