Study on Drug Resistance of 103 Strains of

Objective To investigate the drug resistance of 103 strains of Neisseria gonorrhoeae to 5 antibiotics and the prevalence of penicillinase-producing Neisseria gonorrhoeae(PPNG) and high-level tetracycline resistant Neisseria gonorrhoeae(TRNG) isolated from Futian District Institute for Prevention and Control of Chronic Diseases during the period of 2008-2011.Methods Agar dilution method was used to determine minimum inhibitory concentrations(MICs) to ceftriaxone,spectinomycin,ciprofloxacin,tetracycline and azithromycin.β-lactamase was tested using nitrocefin disk.Results Among 103 strains of Neisseria gonorrhoeae,35 strains of PPNG(34.0%) and 62 strains of TRNG(60.2%) were detected.The resistance to ciprofloxacin accounted for 96.1%,including 51(49.5%) highly resistant strains(MIC≥16 mg/L).The resistance to azithromycin accounted for 16.5%.No strain was found to be resistant to ceftriaxone and spectinomycin,which both had strong antibiotic activity.Conclusions It is the effective method to reduce drug resistant Neisseria gonorrhoeae by continuously monitoring the changes of antibiotic resistance of Neisseria gonorrhoeae in clinical practice.