Clinical observation of insulin glargine combined with acarbose on type 2 diabetes mellitus patients

Objective:To observe clinical effect of insulin glargine combined with acarbose against type 2 diabetes mellitus.Methods: 42 patients with T2DM inadequately controlled by oral antidiabetic drugs were randomly divided into the treatment group and the control group(each group 21 cases).In the control group,p atients were given premixed insulin(Novolin 30R),while in the treatment group were given insulin glargine combined with acarbose.The treatment time of these two groups lasted for 12 weeks. The situation of reaching target of glucose,the incidence of hypoglycemia and the changes of body mass index(BMI) and waist circumference were observed before and after treatment. Results: The FBG,2hPG,HbA1C value of two groups decreased than that before treatment(P0.01).The treatment success rate has no statistical significance between two groups in which reaching the target efficiency of treatment group was better than that of control group.The incidence of hypoglycemia in the treatment group was significantly lower than that in the control group in which 2(9.5%) cases were in the treatment group and 5(23.8%) cases were in the control group(P0.05). Conclusion: The treatment program of insulin glargine combined with acarbose against type 2 diabetes mellitus can significantly improve pancreatic islets β function, and can reduce the level of blood glucose and incidence of hypoglycemia, which has significantly clinical efficiency,and be ideal combination therapy.