Effectiveness observation for patients with type 2 diabetes mellitus treated by nateglinide plus insulin glargine

OBJECTIVE To explore the clinical efficacy of nateglinide plus insulin glargine treatment for type 2 diabetes mellitus.METHODS Fifty patients with initial type 2 diabetes were chosen by the method of randomness and control,and were subcutaneously treated with insulin glargine one time a day,then the daily dose was adjusted to achieve and maintain fasting glucose levels between 5.0-8.0mmol/L.While all the subjects were orally given with the combination of nateglinide three times a day,then the daily dose was adjusted to achieve and maintain postprandial glucose levels between 8.0-10.0mmol/L.The effectiveness of combined treatment after 2 months was observed.RESULTS The levels of FPG,2hPG,HbA1c were all significantly lowered,and there was a significant difference compared with pre-treatment(P﹤0.01).The first-phase insulin release(1PH)was markedly improved after combined treatment.CONCLUSION The therapy of nateglinide plus insulin can affectively induce serum glucose control in initial type 2 diabetes,especially in patients with making the first-phase insulin release better.