2008•Lishizhen Medicine and Materia Medica ResearchRequires access
Effects of Xiaoyao San and its Composition Parts of Prescription on the Despair Animal Models of Depression in Mice
Tang Jing
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Abstract
ObjectiveTo study the anti-depressant effects of Xiaoyao San and its composition parts of prescription,so to ex-plore the regularity of Xiaoyao San composition.MethodsThe tail suspension test,forced swimming test and locomotor activity test were adopted in mice,and the antidepressant effects of Xiaoyao San and its different composition parts were observed.ResultsXiaoyao San,single Chaihu,Danggui and Baishao compatibility,and Xiaoyao San without Danggui and Baishao significantly short-ened the immobility time in the forced swimming test and in the tail suspension test in mice,while had no influence on locomotoractivity.Baizhu and Fuling compatibility,Xiaoyao San without Chaihu had no significant influence on the immobility time.ConclusionXiaoyao San has an antidepressant-like effect in the despair animal models of depression in mice.The principal drug Chaihu plays an important role in its anti-depression effect.Inhibiting wood(liver) to support earth(spleen) may be one of the regularity of Xiaoyao San composition.