2009•Journal of Chengdu University of Traditional Chinese MedicineRequires access
Effects of Xiaoyao Power and its Components on Despair Models of Depression in Mice
Zeng Nan
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Abstract
Objective:To compare the anti-depression effects of Xiaoyao Power and its components on despair models of depression in mice,so as to investigate the key composition parts of prescription for its anti-depression effect.Methods: The auto locomotor activity detecting,tail suspension test and forced swimming test were adopted to observe the anti-depression effects of Xiaoyao Power and its components.Results: Compared with control group,Xiaoyao Power,single Chaihu,Danggui and Baishao compatibility,Chaihu with Danggui and Baishao compatibility,Xiaoyao Power without Chaihu,Xiaoyao Power without Danggui and Baishao obviously shorted the immobility time in the tail suspension test and forced swimming test in mice,while the Xiaoyao Power without Chaihu,Danggui and Baishao had no influence on the immobility time in mice.On the other hand,the effect of single Chaihu was better than Danggui and Baishao compatibility,while the effect of Xiaoyao Power without Chaihu was worse than Xiaoyao Power without Danggui and Baishao.The effect of Chaihu with Danggui and Baishao compatibility was superior to Xiaoyao Power,single Chaihu,and Danggui and Baishao compatibility.All experiment groups had no influence on the auto locomotor activity in mice under the test dose.Conclusion: It is suggested that Chaihu,Danggui and Baishao were the key composition parts of Xiaoyao Power for its anti-depression effect.