The changes of peripheral blood T-lymphocyte subsets in pediatric severe hepatitis

Objective To compare the levels of CD3+,CD3+ CD4+ and CD3+ CD8+ T-lymphocytes in peripheral blood between pediatric and adult patients with severe hepatitis.Methods Peripheral blood from 35 children and 30 adults with severe hepatitis was collected.The levels of peripheral blood CD3+,CD3+ CD4+ and CD3+CD8+ T-lymphocytes were detected by flow cytometry.Results Pediatric group,the first year of children with CD3+,CD3+ CD4+ and CD3+ CD8+ T-lymphocytes was significantly higher than the 2 to 6 years old group(P0.01);pediatric group CD3+,CD3+ CD4+ and CD3+ CD8+ T-lymphocytes was significantly higher than the adult group(P0.01);the first year of children with the highest mortality(P0.05).Conclusion Cellular immunity in children and adults is obviously different.the younger,the more severe disease,the higher mortality,the higher number of CD3+,CD3+ CD4+ and CD3+ CD8+ T-lymphocytes.Pediatric and adult hepatitis blood CD3+,CD3+CD4+ and CD3+ CD8+ T-lymphocytes were significantly different.