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[Assesment of the selected T and B lymphocyte subsets in children with newly diagnosed insulin-dependent diabetes mellitus].

H Kowalska, Katarzyna Kądziela, M Wasik, Malgorzata A. Kowalska, Jolanta Rybczyńska, Barbara Rymkiewicz-Kluczyńska

Abstract

The study was performed in 39 children with newly diagnosed insulin-dependent diabetes mellitus. The %age number of CD19+, CD5+/CD20+ B lymphocytes and CD3+, CD4+, CD8+, CD4+/DR+, CD8+/DR+ T lymphocytes subpopulations were investigated in the peripheral blood. Marked, statistically significant increase (p<0.0001) in CD5+ B lymphocytes was revealed in 77% of patients as compared to the healthy control. The elevated number of CD5+ B lymphocytes correlated with presence of activated lymphocytes T (CD4+/DR+ and CD8+/DR+). The total number of CD19+, CCD3+, CD4+, CD8+ lymphocytes was on comparable level in both groups.

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Available abstract

Key concepts: CD5, CD19, CD8, Lymphocyte subsets, CD20, Internal medicine, Medicine, Diabetes mellitus