Distribution of pathogens detected from 4308 blood culture samples and analysis of drug resistance

Objective To study the distribution of common pathogens and drug resistance to common antibiotics in patients with septicemia, and to provide scientific basis for clinically targeted antimicrobial therapy. Methods By using BACTEC-FX BD automatic blood culture system for culturing blood samples, the pathogens identification and resistance test were carried out by automatic microorganism identification instrument(Phoenix-100 BD), and the distribution and drug resistance of pathogens were studied and analyzed. Results Totally 385 strains of pathogens were isolated from 4 308 blood culture samples, with the positive rate of 8.9%, among which 218(56.6%) were Gram-positive bacteria, 140(36.4%) were Gram-negative bacteria, and 27(7.0%) were fungi. The top six pathogens with isolation rate higher than others were Escherichia coli(72 strains, 18.7%), Staphylococcus epidermidis(44 strains, 11.4%),Fungi(27 strains, 7.0%), Staphylococcus auresu(26 strains, 6.8%), Klebsiella pseudomonas(24 strains, 6.2%), Staphylococcus saprophyticus(20 strains, 5.2%). Escherichia coli was found lowest resistant to Imipenem and Meropenem,while Staphylococcus epidermidis and Staphylococcus auresu was lowest resistant to Linezolid and Nitrofurantoin.Conclusion The main pathogens of septicemia are Gram-positive bacteria, with various conditional pathogenic bacteria on the rise. The majority of pathogens are multi-drug resistant to antibiotics. Clinical physicians should have persistence to actively prevent and control nosocomial cross-infections.