Appling effect of small dose misoprostol tablet in induced labor of late pregnancy

Objective To explore the efficacy and safety of small dose of misoprostol tablet to the induced labor for late pregnancy. Methods 100 pregnant women( pregnancy≥38 weeks,and cervical ripeness score 2-6 points) with single birth and first gestation were divided into the misoprostol group(n=50) and the oxytocin group(n=50).The misoprostol group was given misoprostol 25 μg(1/8 tablet) placed in the posterior fornix of vagina,after 6 hours,it was not in labor,patients could be repeatedly administered 1 time.and a day the most ≤50 μ g;the oxytocin group was given 0.5% or 1%oxytocin for continue intravenous infusion,6-8 h/d,up to a maximum of 72 h. Induction effect,the time of from the first dose to labor,total labor time,the rate of cesarean section of the two groups were compared. Results The induction success rate in the misoprostol group was higher than that in the oxytocin group(P0.05).The effective rate of induction of in the misoprostol group [labor beforecervical score 2-4 points(including 4 points)](89.3%) was higher than that of the oxytocin group(32%)(P0.05).The time of from the first dose to labor in the misoprostol group was obviously shorter than that in the oxytocin group(P0.01).Cesarean section rate in the misoprostol group was significantly lower than that of the oxytocin group(P0.01). Conclusion The effect of a small dose of misoprostol(25 μ g every time) with vaginal administration for promoting cervical ripening in late pregnancy women is sure,it is easy to be accepted by puerperae with little side effect,and it is worthy of clinical promotion,especially it is superior for patients having vaginal delivery conditions with immature cervical conditions.