Applying of Small Dose of Misoprostol in the Induction of Labor for Term Pregnancy(Clinical Analysis of 50 Cases)

Objective To discuss the efficacy and safety of small doses of misoprostol in the induction of labor in term pregnancy.Methods A total of 100 primipara women at term pregnancy with single birth were divided randomly into two groups,with 50 cases for each: Misoprostol 25μg was given by vaginal drug administration,repeated the same dose medication after 6 hours if no labor,and the total daily dose was less than 50 μg in Misoprostol group.Oxytocin 5 U/L was injected intravenously in oxytocin group.Results Compared with oxytocin group,the effective rate of labor in misoprostol group was higher(96% vs.76%,P0.01).The duration from the last time medication to labor onset,the time of total stage of labor and the uterine-incision delivery rate was 5.48±2.44 hours,5.59±2.56 hours and 4% respectively in misoprostol group,all of them were less than 8.26±6.75 hours,8.65±7.34 hours and 36% respectively in oxytocin group(P0.05 or P0.01).But precipitate delivery rate of misoprostol group was obviously higher than that of oxytocin group(22% vs.2%,P0.01) There was no difference in postpartum hemorrhage volume and neonatal asphyxia rate between two groups(P0.05).Conclusion It is safe,effective,economic and convenient of small dose misoprostol in the induction of labor for term pregnancy,and worthy of clinic application in basal hospital.