EFFECTS OF MISOPROSTOL ON INDUCED LABOR FOR PROLONGED PREGNANCY

Objective:To evaluate the effects of misoprostol on induced labor for prolonged pregnancy.Methods:120 prolonged pregnancy lying-in women were randomly divided into misoprostol group and oxytocin group(n=60) . The lying-in women in misoprostol group were given misoprostol at posterior fornix from the initial dose of 25μg;and misoprostol could be repeatedly used 6h later if no effective uterine contraction. The lying-in women in oxytocin group were given oxytocin routinely. Induced labor success rate,cesarean section rate,uterine neck Bishop score,fetal heart rate and amniotic fluid properties of these 2 groups were observed.Results:In misoprostol group,53 women labored in 12h,which occupied 88.3%;in 48h labored 58 cases(96.7%);the cesarean section rate of misoprostol group were 28.3%(17/60) . The above indexes of misoprostol group had obvious differences compared with oxytocin group(P0.01) . There had no obvious differences between misoprostol group and oxytocin group about fetal heart rate before and after medication,amniotic fluid pollution,neonatal score and 24h bleeding amount(P0.05) .Conclusions:Misoprostol is an effective drug in cervical ripening promoting and can get high induced labor rate,it plays important role in induced labor for prolonged pregnancy.