Effect evaluation of Aripiprazole combined with Venlafaxine in the treatment of Major depressive disorder

Objective:To observe the efficacy and safety of Aripiprazole combined with Venlafaxine in the treatment of major depressive disorder.Methods:56 patients with major depression disorder were randomly divided into observation group(28 cases) and control group(28 cases),Aripiprazole and Venlafaxine were used in observation group,and Venlafaxine was only used in control group,treatment for 8 weeks.All the patients were evaluated with HAMD,HAMA,clinical global impression scale(CGI-SI) and treatment emergent symptom scale(TESS) before treatment and at the end of 1st,2nd,4th,8th week.Results:Two groups of HAMD and HAMA score after 8 weeks of treatment than before treatment differences were significant((t=2.13,1.32,P0.01);the differences of HAMD scores of 2nd,6th,8th weeks and HAMA scores of 2nd,6th weeks between the two groups were significant(t=2.03~3.00,P0.05~0.01);total clinical effective rate in observation group(82%) was significantly better than that in control group(57%)(χ2=4.139,P0.05);Two groups of TESS score difference was significant((t=2.42,P0.05).Conclusion:Aripiprazole combined with Venlafaxine is effective and safe in the treatment of major depressive disorder.