Dynamic and clinical study of interleukin-12 level in peripheral venous blood in patients with multiple trauma

Objective To observe the dynamic and clinical study of interleukin-12 levels in peripheral venous blood in patients with multiple trauma.Methods ELISA was applied to measure the IL-12 levels in peripheral venous blood in 36 patients with multiple trauma at the first、third、seventh and fourteenth day.15 healthy persons were taken for the control group.Result The IL-12 levels at every time point in patients with multiple trauma were higher than that of the control group (P0.05).The IL-12 levels in the group of ISS≥16 were higher than that of the group of ISS16(P0.05).The IL-12 levels in patients with Systemic Inflammatory Response Syndrome(SIRS)and Multiple Organ Dysfunction Syndrome(MODS)were higher than that of those without SIRS and MODS(P0.05).Conclusion The IL-12 levels in peripheral venous blood in patients with multiple trauma have correlation with the injury severity.The dynamic measure of IL-12 change may have important clinical significance.