Studies on anti inflammatory response and immunosupression in posttraumatic patients with multiple organ dysfunction syndrome

Objective Thirty-three traumatic patients[mean injury severity score (ISS)21.8±5.8, 18 cases ISS 18-25,15 cases ISS≥25]with MODS were involved in this research to testify their parameters of CARS and immunity.Methods ELISA was utilized to detect plasma interleukin(IL)-4,10,12,13.Results (1)?IL-4 was negatively measured in all patients whether SIRS, organ failure existed or not.(2)? With the increase of number of organ failure, level of IL-10 was elevated (P0.05). IL-10 of SIRS and dead groups was very significantly increased than that of non-SIRS group and the survival group.(3)?High IL-12 concentration was found in the survival group than that in the dead group (P0.05).(4)?No significant difference of IL-13 was discovered between SIRS and non SIRS groups,but higher than the control group(P0.05). Conclusion Posttraumatic patients with elevated plasma IL-10 and low plasma IL-12 may be susceptible to MODS with high mortality.